DOES ISOTRETINOIN CAUSE LIMB REDUCTION DEFECTS?
نویسندگان
چکیده
منابع مشابه
Limb reduction defects text.PDF
Of all congenital anomalies, limb reduction defects maintain a high profile with the public. In the early 1960s, high rates of limb reductions were associated with expectant mothers taking the drug thalidomide. As a result of this, congenital anomaly surveillance systems were established to try and prevent further such episodes. In the late 1980s limb reductions were found to be associated with...
متن کاملRisk indicators of reduction limb defects.
The birth of a child with a reduction limb defect (RLD) was evaluated in relation to vaginal bleeding, threatened abortion, and other complications of pregnancy, placental weight, birth weight, family history, parental age, and the outcome of previous pregnancies. The material consisted of 453 cases of reduction limb defect and an equal number of non-malformed controls matched for time and plac...
متن کاملCongenital scalp defects with distal limb reduction anomalies.
Scalp defects occur as an isolated abnormality or in association with other malformations, and familial cases were first reported by Feud et all in 1945 and Tisserand-Perier2 in 1953. In 1945, Adams and Oliver3 were the first to report the distinct association of scalp defects with distal limb anomalies. Later reports in the mid-1970s by Burton et al4 and Scribanu and Temtamy5 showed that the c...
متن کاملLimb reduction defects in endothelial nitric oxide synthase-deficient mice.
Nitric oxide synthases are a family of enzymes capable of converting l-arginine to l-citrulline with the subsequent release of nitric oxide (NO). NO has been shown to have multiple biologic effects depending on the isoform responsible for its production and its tissue of origin. Murine endothelial nitric oxide synthase (eNOS) is encoded by Nos3, located on mouse chromosome 5. NO produced from t...
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Question: In patients with acne vulgaris, does treatment with isotretinoin increase the risk of depression? Design: A case-crossover study was performed among subjects who received 1 or more isotretinoin prescriptions from 1984 through 2003. Setting: Data were obtained from the Régie de l’Assurance Maladie du Québec (RAMQ) and Quebec’s hospital discharge (Med-Echo) administrative databases. Pat...
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ژورنال
عنوان ژورنال: The Lancet
سال: 1985
ISSN: 0140-6736
DOI: 10.1016/s0140-6736(85)90370-8